KCNMA1‐Related Episodes of Behavioral Arrest and Loss of Postural Reflexes: A Critical Reappraisal - Archive ouverte HAL
Article Dans Une Revue Movement Disorders Clinical Practice Année : 2024

KCNMA1‐Related Episodes of Behavioral Arrest and Loss of Postural Reflexes: A Critical Reappraisal

Emmanuel Roze
  • Fonction : Auteur
Laura Silveira-Moriyama
Smaranda Leu-Semenescu
  • Fonction : Auteur
Nathalie Villeneuve
  • Fonction : Auteur
Bérénice Lecardonnel
  • Fonction : Auteur
Claudio de Gusmao
Agathe Roubertie

Résumé

Abstract Background KCNMA1 ‐linked channelopathy is characterized by neurodevelopmental disorder, epileptic seizures and non‐epileptic paroxysmal episodes. Objectives To describe the phenotype of paroxysmal non‐epileptic episodes related to KCNMA1 pathogenic variants. Methods Videos of paroxysmal episodes were reviewed according to a standardized protocol by a group of movement disorders experts. Results Fourteen videos were reviewed (6 previously published patients and a new patient). The typical pattern of an episode was (i) facial changes including dyskinetic movements of tongue and jaws (ii) behavioral arrest (iii) loss of postural reflexes that could be associated with focal body stiffness, eventually leading to fall (iv) rapid recovery without post‐ictal drowsiness. Attacks were brief, with a high daily frequency, occasionally triggered by emotion, and dramatically improved by psychostimulant therapy in three patients. Conclusions KCNMA1 ‐related attacks are clearly distinguishable from paroxysmal dyskinesia, cataplexy or episodic ataxia indicating a unique phenomenological entity whose recognition will enhance accurate diagnosis and treatment.
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hal-04815747 , version 1 (03-12-2024)

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Emmanuel Roze, Laura Silveira-Moriyama, Smaranda Leu-Semenescu, Nathalie Villeneuve, Bérénice Lecardonnel, et al.. KCNMA1‐Related Episodes of Behavioral Arrest and Loss of Postural Reflexes: A Critical Reappraisal. Movement Disorders Clinical Practice, 2024, ⟨10.1002/mdc3.14289⟩. ⟨hal-04815747⟩
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