Topology effects in photodynamic therapy with phthalocyanine nanocarriers - Archive ouverte HAL
Article Dans Une Revue Materials Advances Année : 2024

Topology effects in photodynamic therapy with phthalocyanine nanocarriers

Résumé

Two different amphiphilic copolymers, a random copolymer (RCP) and a block copolymer (BCP), have been used to encapsulate a far-red photosensitizing hydrophobic zinc phthalocyanine while forming self-assembled nanocarriers of different topology: self-folded single-chain nanoparticles (SCNPs) and star-like aggregates (SLAs), respectively. Different copolymer/phthalocyanine ratios have been tested to assess their effect on structural properties which were determined by small-angle X-ray scattering (SAXS) measurements. The relevance of these materials as photosensitizer nanocarriers for photodynamic therapy (PDT) has been studied against human breast cancer cells (MCF-7). A better PDT effect was found for the SCNP-Pc2x (100 mg mL1 ) excited at 800 nm with a pulsed laser than for the SLA-Pc2x under identical conditions. Conversely, irradiation at slightly lower wavelengths (740 nm) of MCF-7 cells incubated with SLA-Pc2x resulted in a notorious PDT effect when compared to that observed for MCF-7 cells incubated with the SCNP-Pc2x. These systems represent new strategies for the encapsulation of photosensitizers for photodynamic therapy.

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hal-04814440 , version 1 (02-12-2024)

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Davide Arena, Ümit İşci, Mélanie Onofre, Christophe Nguyen, Zeynel Şahin, et al.. Topology effects in photodynamic therapy with phthalocyanine nanocarriers. Materials Advances, 2024, ⟨10.1039/d4ma00524d⟩. ⟨hal-04814440⟩
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