Biofilm formation in Streptococcus suis: in vitro impact of serovars and assessment of coinfections with other porcine respiratory disease complex bacterial pathogens - Archive ouverte HAL
Article Dans Une Revue Veterinary Research Année : 2024

Biofilm formation in Streptococcus suis: in vitro impact of serovars and assessment of coinfections with other porcine respiratory disease complex bacterial pathogens

Rubén Miguélez-Pérez
  • Fonction : Auteur
Oscar Mencía-Ares
Connectez-vous pour contacter l'auteur
César B. Gutiérrez-Martín
  • Fonction : Auteur
Alba González-Fernández
  • Fonction : Auteur
Máximo Petrocchi-Rilo
  • Fonction : Auteur
Mario Delgado-García
  • Fonction : Auteur
Sonia Martínez-Martínez
  • Fonction : Auteur

Résumé

AbstractStreptococcus suis is a worldwide pathogen that impacts the swine industry, causing severe clinical signs, including meningitis and arthritis, in postweaning piglets. A key virulence mechanism of S. suis is biofilm formation, which improves its persistence and resistance to external factors. Here, we assessed the in vitro biofilm formation of 240 S. suis isolates from Spanish swine farms and evaluated the effects of serovars (SVs) and coinfections with other porcine respiratory disease complex (PRDC) pathogens. Our study revealed significant heterogeneity in biofilm formation among S. suis SVs. Notably, SV2 resulted in the lowest degree of biofilm formation, in contrast with the high biofilm-forming capacities of SV1, SV7, and SV9. Other PRDC pathogens, including Actinobacillus pleuropneumoniae, Glaesserella parasuis, and Pasteurella multocida, formed biofilms, although they were generally less robust than those of S. suis (except for SV2), which contrasts with the high biofilm formation of Staphylococcus hyicus. Coinfections enhanced biofilm formation in mixed cultures of S. suis, particularly with P. multocida. Other coinfections revealed variable results in pathogen interactions, suggesting the potential of biofilms for increased persistence and pathogenicity in coinfections. In conclusion, this study underscores the importance of serovar-specific differences in biofilm formation among S. suis isolates, with significant implications for pathogenicity and persistence. The heterogeneous biofilm formation observed in coinfections with other PRDC pathogens reveals a complex interplay that could exacerbate disease severity. These findings provide a foundation for further research on biofilm mechanisms to mitigate the impact of PRDC in the swine industry.
Fichier principal
Vignette du fichier
13567_2024_Article_1412.pdf (5.52 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-04813474 , version 1 (02-12-2024)

Identifiants

Citer

Rubén Miguélez-Pérez, Oscar Mencía-Ares, César B. Gutiérrez-Martín, Alba González-Fernández, Máximo Petrocchi-Rilo, et al.. Biofilm formation in Streptococcus suis: in vitro impact of serovars and assessment of coinfections with other porcine respiratory disease complex bacterial pathogens. Veterinary Research, 2024, 55 (1), pp.157. ⟨10.1186/s13567-024-01412-9⟩. ⟨hal-04813474⟩

Collections

ARINRAE-VR ARINRAE
0 Consultations
0 Téléchargements

Altmetric

Partager

More