This paper focuses on the sistrum, the well-known instrument strongly connected to what modern scholars define nowadays as Isism, found on multiple occasions during the Graeco-Roman period in the geographic area of the Danubian and Balkan regions. These include the realia as well as portrayals on a variety of archaeological finds, for instance: wall plaster, altars, rock-cut reliefs, funerary monuments, gems and so on. The main purpose of the paper is to offer a contextualization and subsequently, an interpretation of the finds discovered so far in the region mentioned above.