Identification of new bioactive molecules in platelet preparation, storage, and transfusion reactions for improved transfusion management - Archive ouverte HAL
Article Dans Une Revue Scientific Reports Année : 2024

Identification of new bioactive molecules in platelet preparation, storage, and transfusion reactions for improved transfusion management

Résumé

Platelet concentrates (PCs) intended for transfusion contain bioactive molecules that can be considered Biological Response Modifiers (BRMs), mainly originating from plasma regardless of the preparation process. During storage, NGAL and GDF-15 levels increase in single donor apheresis platelet concentrates (SDA-PC), whereas in buffy coat platelet concentrates (BC-PC), the levels of MIP1α, MCP-3, and HSAA increase, and GDF-15 levels decrease. These molecules, primarily released by leukocytes, may contribute to adverse reactions (ARs) following a PC transfusion. Notably, in SDA-PC or BC-PC transfusions that result in ARs, the levels of NGAL, HSAA, and GDF-15 are significantly elevated, while the levels of MDC and CX3CL1 are significantly reduced compared to transfusions without ARs. These biomarkers could potentially serve as predictors for PCs-induced ARs.

Dates et versions

hal-04806321 , version 1 (27-11-2024)

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Citer

Anne-Claire Duchez, Charles-Antoine Arthaud, Marie-Ange Eyraud, Amélie Prier, Marco Heestermans, et al.. Identification of new bioactive molecules in platelet preparation, storage, and transfusion reactions for improved transfusion management. Scientific Reports, 2024, 14 (1), pp.29381. ⟨10.1038/s41598-024-80632-7⟩. ⟨hal-04806321⟩
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