The role of topology and mechanics in uniaxially growing cell networks - Archive ouverte HAL
Article Dans Une Revue Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences Année : 2020

The role of topology and mechanics in uniaxially growing cell networks

Résumé

In biological systems, the growth of cells, tissues and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbours in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or strain-driven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth.

Domaines

Biophysique

Dates et versions

hal-04799983 , version 1 (23-11-2024)

Identifiants

Citer

Alexander Erlich, Gareth Jones, Françoise Tisseur, Derek Moulton, Alain Goriely. The role of topology and mechanics in uniaxially growing cell networks. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2020, 476 (2233), pp.20190523. ⟨10.1098/rspa.2019.0523⟩. ⟨hal-04799983⟩

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