An electrochemical aptamer-based biosensor for arginin-vasopressin
Résumé
Aptamers have gained recently widespread attention as biorecognition elements; they are an attractive alternative to antibodies, especially for small molecules detection due to the small surface area of the latter [1] . On the other hand, electrochemical biosensors became essential tools for biomarkers detection due to their high sensitivity (detection limits to the femtomolar level) and the possibility to be miniaturized into portable devices. [2]. Here, we present the elaboration of an electrochemical aptasensor for arginin vasopressin which is an important diagnostic biomarker for diseases such as diabetes insipidus or SIADH syndrom. This new technique aims to overcome the complexity of the currently used techniques such as radioimmunoassays (RIA) and chromatography (LC) mass spectrometry (MS) while detecting vasopressin in physiological liquids (picomolar range). References: 1 J. Baur, C. Gondran, M. Holzinger, E. Defrancq, H. Perrot, et S. Cosnier, Anal. Chem.,2010 vol. 82, no 3, p. 1066‑1072 2 K.-M. Song, S. Lee, et C. Ban, Sensors,2012, vol. 12, p. 612‑31 3 B. Chovelon, E. Fiore, P. Faure, E. Peyrin, et C. Ravelet, Anal. Chim. Acta, 2018, vol. 1001, p. 143‑150