MODOMICS: a database of RNA modifications and related information. 2023 update - Archive ouverte HAL
Article Dans Une Revue Nucleic Acids Research Année : 2024

MODOMICS: a database of RNA modifications and related information. 2023 update

Andrea Cappannini
Angana Ray
Elżbieta Purta
Sunandan Mukherjee
Pietro Boccaletto
S Naeim Moafinejad
Antony Lechner
Charles Barchet
Bruno P. Klaholz
Filip Stefaniak
Janusz M Bujnicki

Résumé

The MOD OMICS database w as updated with recent data and no w includes ne w dat a t ypes related to RNA modifications. Changes to the database include an expanded modification catalog, encompassing both natural and synthetic residues identified in RNA structures. This addition aids in representing RNA sequences from the RCSB PDB database more effectively. To manage the increased number of modifications, adjustments to the nomenclature sy stem w ere made. Updates in the RNA sequences section include the addition of new sequences and the reintroduction of sequence alignments for tRNAs and rRNAs. The protein section was updated and connected to str uct ures from the RCSB PDB database and predictions b y AlphaFold. MOD OMICS no w includes a data annotation system, with 'Evidence' and 'Estimated Reliability' features, offering clarity on data support and accuracy. T his sy stem is open to all MODOMICS entries, enhancing the accuracy of RNA modification data representation.
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hal-04789882 , version 1 (19-11-2024)

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Andrea Cappannini, Angana Ray, Elżbieta Purta, Sunandan Mukherjee, Pietro Boccaletto, et al.. MODOMICS: a database of RNA modifications and related information. 2023 update. Nucleic Acids Research, 2024, 52, pp.D239 - D244. ⟨10.1093/nar/gkad1083⟩. ⟨hal-04789882⟩
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