Au(I)-catalyzed Regioselective Hydrogen Isotope Labeling of Indoles 6f, 8
Résumé
The gold(I)-catalyzed hydrogen isotope exchange reaction on indoles and related heterocycles is described under mild conditions and low catalyst loadings, using CD3OD and D2O as readily available deuterium sources. C3-unsubstituted indoles are labeled at the C3 position with exquisite regioselectivity, while C3-substituted indoles are labeled at the C2 position. The method is also applicable to the regioselective tritiation of indoles. Mechanistic studies revealed the involvement of aurated indoles as key intermediates
| Origine | Fichiers produits par l'(les) auteur(s) |
|---|