Data quality in health information systems (HIS) is essential for informed decision-making in the health sector, particularly in sub-Saharan Africa (SSA) where these systems face many challenges like resource limitations and weak infrastructure. This systematic review assessed the quality of HIS data in the region, focusing on the dimensions, and factors influencing this quality. It highlights the importance of systematic evaluation, ongoing training for data collectors in the analysis and use of data for decision-making, and the adoption of information and communication technologies in the healthcare system to improve data quality. These findings point the way to better use of health data and the need for a more integrated approach to digital health in SSA.