ABSTRACT Background The integrated care for older people (ICOPE) program, developed by the World Health Organization, serves as a public health initiative to maintain older adults’ functional abilities and promote healthier aging. Here, we adapted the ICOPE approach to assess overall prevalence of frailty in rural and semi‐urban areas. We also investigated health‐related quality of life and physical activity and sedentary behavior in older people. Methods The FRAGING multicenter cohort study was performed on screening days dedicated to older adults (≥65 years) without chronic disease in a rural area (RU) and in a semi‐urban area (SU). Results The study included a total of 105 participants: 98.4% of participants were frail, with a mean of 4.3 [SD: 2.5] frailties per participant. RU participants had higher number of frailties ( p = 0.02) and a higher percentage of frail participants in the dimensions of health‐related quality of life ( p < 0.0001), socioeconomical level ( p = 0.008), colorectal cancer screening ( p = 0.022), and tetanus booster doses ( p = 0.008). Globally, women were less sedentary than men ( p = 0.02) and engaged more in low physical activity (LPA) than men ( p = 0.01). RU participants engaged more in LPA than SU participants ( p = 0.03). Conclusions The prevalence of frailty is alarmingly underestimated in older adults without chronic disease. This study demonstrated the need to propose appropriate, validated screening tests that consider territorial issues and organization of care delivery. The ICOPE framework serves as a good startpoint for reorganizing person‐centered healthcare pathways.