Studies of initiation of large earthquakes are usually focused on frictional instabilities occurring in the near vicinity of the future rupture. Possible contributions of long‐distance interactions with large‐scale tectonic instabilities remain unknown. Here we analyze seismic catalogs and geodetic time series during a few months preceding the 2013 M = 8.3 deep‐focus Okhotsk earthquake. This deep‐focus event is preceded by four intense seismic clusters in the seismogenic zone. GNSS time series in Kamchatka revealed a transient landward motion episode 1 month prior to the mainshock, consistent with an increase of seismogenic zone loading. This transient loading episode is accompanied by a doubling of the intermediate depth seismicity rate suggesting a transient slab pull as the origin. These observations question the constant subducting velocity hypotheses and may have implications in the understanding of the long‐distance along‐slab stress interactions and in their contribution to initiation of large deep‐focus earthquakes.