Communication Dans Un Congrès Année : 2024

Production cross section measurements of the natPd(α,x)111Ag reaction

Résumé

The radionuclides used in targeted radionuclide therapy emit charged particles, such as α, β- and Auger electron, that makes possible the delivery of a significant dose to the tumour cells while sparring the healthy tissues surrounding them. The radioisotope 111Ag (t1/2 = 7.45 days, Emax,β- = 1.04 MeV) is a β- emitter that is promising for this kind of application. Its low energy β- have a medium tissue penetration of average 1.8 mm which enables the targeting of medium tumours. Additionally, its γ-rays at 245 keV (1.3 %) and 342 keV (6.7 %) are well suited for SPECT imaging which is helpful for monitoring more precisely the in vivo dose delivered. Several routes have been studied to produce 111Ag either with research reactors, cyclotrons or photonuclear reactions. The use of helium ions (alpha route) has not been studied yet. Only two teams have made measurements for the production cross sections of the reaction natPd(α,x)111Ag and none for 110Pd(α,x)111Ag. For this reason, several measurements for natPd(α,x)111Ag have been performed at the GIP Arronax with an α beam of 68 MeV to get experimental data above 50 MeV to better define the peak region between 40 and 50 MeV. The “stacked-foils” method has been used during our experiments. The intensity of the beam has been monitored through the natAl(α,x)24Na nuclear reaction. A HPGe detectors was used to perform the γ-spectrometry of each foil: short acquisition were done directly after the irradiation to measure 110m,110Pd and longer ones days after to measure 111Ag. The experimental data obtained will be confronted with the literature and with TENDL 2023. The indirect production of 111Ag with 110m, 110Pd will also be studied to try to assess their contribution.

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hal-04780637 , version 1 (13-11-2024)

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  • HAL Id : hal-04780637 , version 1

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Laurine Puren, Arnaud Guertin, Etienne Nigron, Ferid Haddad, Vincent Métivier. Production cross section measurements of the natPd(α,x)111Ag reaction. Tumour targeting, Imaging, RadiotherapieS, Oct 2024, Erquy, FR, France. ⟨hal-04780637⟩
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