A newborn F-box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids - Archive ouverte HAL
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2024

A newborn F-box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids

Dongying Xie
Yiming Ma
Yiqing Liu
Qiutao Ding
Gefei Huang
Zongwei Cai
Zhongying Zhao

Résumé

The establishment of reproductive barriers such as postzygotic h ybrid i ncompatibility (HI) remains the key to speciation. Gene duplication followed by differential functionalization has long been proposed as a major model underlying HI, but little supporting evidence exists. Here, we demonstrate that a newborn F-box gene, Cni-neib-1 , of the nematode Caenorhabditis nigoni specifically inactivates an essential phosphoglucomutase encoded by Cbr-shls-1 in its sister species Caenorhabditis briggsae and their hybrids. Zygotic expression of Cni-neib-1 specifically depletes Cbr- SHLS-1, but not Cni- SHLS-1, in approximately 40 min starting from gastrulation, causing embryonic death. Cni-neib-1 is one of thirty-three paralogues emerging from a recent surge in F-box gene duplication events within C. nigoni , all of which are evolving under positive selection. Cni-neib-1 undergoes turnover even among C. nigoni populations. Differential expansion of F-box genes between the two species could reflect their distinctive innate immune responses. Collectively, we demonstrate how recent duplication of genes involved in protein degradation can cause incidental destruction of targets in hybrids that leads to HI, providing an invaluable insight into mechanisms of speciation.

Dates et versions

hal-04776549 , version 1 (11-11-2024)

Identifiants

Citer

Dongying Xie, Yiming Ma, Pohao Ye, Yiqing Liu, Qiutao Ding, et al.. A newborn F-box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (46), ⟨10.1073/pnas.2418037121⟩. ⟨hal-04776549⟩
14 Consultations
0 Téléchargements

Altmetric

Partager

More