ass Spectrometry Imaging based on FTICR: application to Pt based anticancer drugs detection in human tissue
Résumé
Peritoneal carcinomatosis is a common extension of colon cancer. Platinum derivatives, such as oxaliplatin, are common metallodrugs applied during the Heated Intraoperative Chemotherapy (HIPEC), which consists in a local application of a high concentration of drug. During the HIPEC procedure, the metallodrug circulates into the peritoneal cavity and can affect other organs such as ovaries. Knowledge of penetration and distribution of this drug within the ovaries will help to better understand the effects of the drug on ovary functionality.