The current study presents an investigation on flow patterns, pressure-drop and heat transfer coefficient for the refrigerants R1233zd(E) and R245fa flowing at saturation temperatures (T sat ) between 75 • C and 95 • C inside a horizontal 2 mm diameter tube. Experimental results are reported for mass velocities of 176-570 kg/m 2 s and heat fluxes of 18.1-54.5 kW/m 2 . As expected, the pressure gradient increases as the mass velocity increases and the saturation temperature decreases. Flow image analysis indicated that the pressure gradient peak is associated with disturbance interfacial waves damping. Heat transfer coefficient data indicated strong contribution of nucleate boiling effects for most of the experimental conditions. The higher the saturation temperature and the heat flux, the higher the heat transfer coefficient, regardless of the vapor quality range. In general, the effect of mass velocity on the heat transfer coefficient was only marginal, with exception of low T sat and heat flux conditions. Two of 20 pressure-drop prediction methods predicted more than 90% of the database within error bands of ±30%. Overestimation of heat transfer coefficient data was verified for most of the 16 evaluated prediction methods, especially at high T sat . Only two methods predicted more than 80% of data within an error band of ±30%.