The presence of organic matter in carbonaceous chondrites provides valuable information about the early composition of the Solar System. Although they are considered primitive, the majority of these chondrites have undergone secondary processes subsequent to their formation. These processes, such as aqueous alteration, have altered their composition. The effect of aqueous alteration on minerals is well known, but the effect on organic matter and/or on an organo-mineral system have been little studied. Here, we report experimental results devoted to investigate the chemical evolution of a hypothetical initial chondritic material subjected to hydrothermal alteration under reducing conditions at low-temperature. The mixtures consist of different anhydrous minerals (peridot, feldspar, troilite) together with hexamethylenetetramine (HMT) chosen as a model molecule inherited from the interstellar grains. After different times at 80°C, the large molecular diversity formed is highly influenced by the presence and the nature of the minerals, as highlighted in particular by the evolution of the amide produced. The presence of minerals in the mixture appears to influence the reactivity of the system more through the formation of salts and chelates than through surface adsorption mechanisms. The most pronounced effect is observed in the presence of troilite, both in the degradation of HMT and in the abundance of amides formed. The study of the mutual influence of minerals and organic matter, and their intrinsic transformations in the media during the processes, could help to understand about the origin of organic molecules observed in carbonaceous chondrites.