Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study - Archive ouverte HAL
Article Dans Une Revue Clinica Chimica Acta Année : 2025

Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study

Anthony Desaegher
  • Fonction : Auteur
Victor Marin
  • Fonction : Auteur
Brigitte Colombiès
  • Fonction : Auteur
Margaux Lauga
  • Fonction : Auteur
Sonia Alloug
  • Fonction : Auteur
Selen Kalkan
  • Fonction : Auteur
Gladys Castaing-Mouhica
  • Fonction : Auteur
Geneviève Lacape
  • Fonction : Auteur
Benoit Rucheton
  • Fonction : Auteur
Julien Doublet
  • Fonction : Auteur
Sandrine Dabernat
  • Fonction : Auteur
Marie-Lise Bats
  • Fonction : Auteur

Résumé

Abstract The evaluation of the efficacy of a drug is a fundamental step in the development of new treatments or in personalized therapeutic strategies and patient management. Ideally, this evaluation should be rapid, possibly in real time, easy to perform and reliable. In addition, it should be associated with as few adverse effects as possible for the patient. In this study, we present a device designed to meet these goals for assessing therapeutic response. This theranostic device is based on the use of magnetic resonance imaging and spectroscopy for the diagnostic aspect and on the application of the convection-enhanced delivery technique for the therapeutic aspect. The miniaturized device is implantable and can be used in vivo in a target tissue. In this study, the device was applied to rodent glioma models with local administration of choline kinase inhibitor and acquisition of magnetic resonance images and spectra at 7 Tesla. The variations in the concentration of key metabolites measured by the device during the administration of the molecules demonstrate the relevance of the approach and the potential of the device.
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Anthony Desaegher, Victor Marin, Marie-Christine Beauvieux, Brigitte Colombiès, Margaux Lauga, et al.. Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study. Clinica Chimica Acta, 2025, 565 (1), pp.119996. ⟨10.1016/j.cca.2024.119996⟩. ⟨hal-04765936⟩

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