Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates - Archive ouverte HAL
Article Dans Une Revue Journal of Medicinal Chemistry Année : 2024

Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates

Elisa Chazeau
  • Fonction : Auteur
Catherine Paul

Résumé

The development of new fluorescent organic probes effective in the NIR-II region is currently a fastgrowing field and represents a challenge in the domain of medical imaging. In this study, we have designed and synthesized an innovative series of aza-BODIPYs emitting in the NIR-II region. We have investigated the effect of differently water-solubilizing groups on the photophysical properties of the compounds, but also on their in vitro and in vivo performance, after bioconjugation to the antibody trastuzumab. Remarkably, we discovered that the most lipophilic compound unexpectedly displayed the most favorable in vivo properties after bioconjugation. This underscores the profound influence that the functionalization approach for the fluorophore can have on the efficiency of the resulting imaging agent.

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Chimie
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Dates et versions

hal-04757976 , version 1 (29-10-2024)

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Elisa Chazeau, Christol Fabre, Malorie Privat, Amélie Godard, Cindy Racoeur, et al.. Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates. Journal of Medicinal Chemistry, 2024, 67 (5), pp.3679-3691. ⟨10.1021/acs.jmedchem.3c02139⟩. ⟨hal-04757976⟩
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