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SCCS Opinion on Inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products - Submission IV - SCCS/1663/24 – Final Opinion

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SCCS Opinion on Inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products - Submission IV - SCCS/1663/24 – Final Opinion U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven, E. Benfenati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von Goetz The SCCS adopted this Opinion during the plenary meeting on 25 October 2024 (38 Pages) Mise en ligne : 25 October 2024 https://health.ec.europa.eu/publications/sccs-opinion-inhalation-toxicity-fragrance-ingredient-acetylated-vetiver-oil-avo-cas-no-84082-84-8_en https://health.ec.europa.eu/document/download/33f9b700-ed91-47d7-9079-ac9aabbf65d4_en?filename=sccs_o_285.pdf Details Publication date : 25 October 2024 Author : Scientific Committee on Consumer Safety (SCCS) Description SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), J. Ezendam, E. Gaffet, C. L. Galli (Rapporteur), E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven SCCS external experts: E. Benfentati, N. Cabaton, E. Corsini, A. Koutsodimou, H. Louro, W. Uter, N. von Goetz Contact: SANTE-SCCS@ec.europa.eu On request from: European Commission SCCS Number: SCCS/1663/24 Adopted on: 25 October 2024 Conclusion of the opinion: (1) In light of the data provided concerning inhalation toxicity, does the SCCS consider Acetylated Vetiver Oil (AVO) safe when used in sprayable cosmetic products with intended maximum concentrations (IMCs) of 0.9% (w/w) in fragrance pump sprays, 0.05% (w/w) in deodorant sprays and 0.1% (w/w) in hairsprays and body lotion sprays? Having considered the data provided concerning inhalation toxicity and aggregate exposure, the SCCS considers Acetylated Vetiver Oil (AVO) (with 1% alpha-tocopherol) safe when used at the intended maximum concentrations (IMCs) of 0.9% (w/w) in fragrance pump sprays, 0.05% (w/w) in deodorant sprays and 0.1% (w/w) in hairsprays and body lotion sprays. The findings of an in vitro study using Mucilair™ also support this conclusion. (2) Does the SCCS have any further scientific concerns regarding the use of Acetylated Vetiver Oil (AVO) in cosmetic products? / Keywords: SCCS, scientific opinion, Acetylated Vetiver Oil (AVO), Regulation 1223/2009, Acetylated Vetiver oil – AVO, CAS No 84082-84-8, EC No 282-031-1, SCCS/1663/24 Opinion to be cited as: SCCS (Scientific Committee on Consumer Safety), Opinion on the inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products - Submission IV, preliminary version of 28 February 2024, final version of 25 October 2024, SCCS/1663/24.

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hal-04756600 , version 1 (28-10-2024)

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U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads, J. Ezendam, et al.. SCCS Opinion on Inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products - Submission IV - SCCS/1663/24 – Final Opinion. Scientific Committee for Consumer Safety (SCCS, EC). , 2024, Scientific Committee for Consumer Safety (SCCS, EC). ⟨hal-04756600⟩
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