Pré-Publication, Document De Travail Année : 2024

Titin-dependent biomechanical feedback tailors sarcomeres to specialised muscle functions in insects

Vincent Loreau
Wouter Koolhaas
  • Fonction : Auteur
Eunice Hoyee Chan
  • Fonction : Auteur
Paul de Boissier
  • Fonction : Auteur
Nicolas Brouilly
Sabina Avosani
Aditya Sane
Christophe Pitaval
  • Fonction : Auteur
Stefanie Reiter
  • Fonction : Auteur
Nuno Miguel Luis
Pierre Mangeol
Anne C von Philipsborn
Jean-François Rupprecht
Dirk Görlich
Bianca H Habermann

Résumé

Sarcomeres are the contractile units of muscles that enable animals to move. Insect muscles are remarkable examples because they use extremely different contraction frequencies (ranging from ∼1 to 1000 Hz) and amplitudes for flying, walking and crawling. This is puzzling because sarcomeres are built from essentially the same actin-myosin components. We show here that the giant protein titin is the key to this functional specialisation. I-band titin spans and determines the length of the sarcomeric I-band, and occurs in muscle-type-specific isoforms. Surprisingly, it also rules the length of the force-generating myosin filament in a force feedback mechanism, even though it is not present there. We provide evidence for this model and its validity beyond insects.

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hal-04750619 , version 1 (23-10-2024)

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Vincent Loreau, Wouter Koolhaas, Eunice Hoyee Chan, Paul de Boissier, Nicolas Brouilly, et al.. Titin-dependent biomechanical feedback tailors sarcomeres to specialised muscle functions in insects. 2024. ⟨hal-04750619⟩
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