Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients - Archive ouverte HAL
Article Dans Une Revue Journal of Cellular and Molecular Medicine Année : 2022

Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients

Résumé

The notion of MDSC encompasses a complex series of cell subsets with the capacity to suppress innate and adaptive immune responses. 1 In 2016, divergences in their immunophenotypic definition led to propose a harmonization/standardization of strategies to establish a robust enumeration of MDSC subsets. Thus, in humans, M-MDSC can be characterized in flow cytometry by the minimal CD14 + /CD11b + /CD33 + /HLA-DR -/low immunophenotypic pattern, at variance from granulocytic MDSC that lack CD14 and express bright CD15. 2 The latter are readily identifiable in mice through the Gr marker but this differentiation antigen is lost on human suppressive neutrophils. These cells can be identified in the low-density fraction of leukocytes after Ficoll Hypaque density centrifugation of human PB, which is a time-consuming technique difficult to standardize. 2 MDSC pertain to the physiological mechanisms allowing to regulate and tamper immune responses. As T-regs or B-regs, they are used by tumour cells to favour their escape from the normally very efficient anti-tumoral immune responses. MDSC are also capable of directly inhibiting T-cell functions. This immunosuppressive action in the setting of malignancy is thought to be due to the secretion by tumour cells and MDSC themselves of various anti-inflammatory cytokines such as TGFβ and IL-10 and many other molecules (arginases, NO, ROS, IDO, PGE2). 3,4 The pejorative role of MDSC in favouring tumour expansion, described in solid tumours, 5 has also been reported in various

Fichier principal
Vignette du fichier
J Cellular Molecular Medi - 2022 - Peterlin - Peripheral levels of monocytic myeloid‐derived suppressive cells before and.pdf (884.83 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04743410 , version 1 (18-10-2024)

Licence

Identifiants

Citer

Pierre Peterlin, Camille Debord, Marion Eveillard, Alice Garnier, Amandine Le Bourgeois, et al.. Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients. Journal of Cellular and Molecular Medicine, 2022, 26 (21), pp.5486 - 5492. ⟨10.1111/jcmm.17576⟩. ⟨hal-04743410⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More