Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years - Archive ouverte HAL
Article Dans Une Revue Scientific Reports Année : 2022

Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

1 INSERM SC10 – US19 - INSERM SC10 – US19 Essais thérapeutiques et maladies infectieuses
2 UVE - Unité des Virus Emergents
3 CIC Nantes - Centre d’Investigation Clinique de Nantes
4 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
5 CHU Pitié-Salpêtrière [AP-HP]
6 CIC 1417 - CIC Cochin Pasteur
7 Hôpital Cochin [AP-HP]
8 CIC Lille - Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301
9 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
10 CIC-EC 1408 - Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
11 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
12 CIRI - Centre International de Recherche en Infectiologie
13 Hôpital de la Croix-Rousse [CHU - HCL]
14 CIC - Centre d'Investigation Clinique [Hôpital de la Conception - APHM]
15 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
16 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
17 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
18 Hôpital Henri Mondor
19 CIC Henri Mondor - Centre d'Investigation Clinique Henri Mondor
20 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
21 DYNAMICURE - Dynamique Microbienne associée aux Infections Urinaires et Respiratoires
22 CHU Caen
23 CIC-1427 - CIC Saint Louis
24 AP-HP - Hopital Saint-Louis [AP-HP]
25 VBIC - Virulence Bactérienne et Infections Chroniques
26 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
27 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
28 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
29 CHU Gabriel Montpied [Clermont-Ferrand]
30 CIC 1405 - Centre d'Investigation Clinique [CHU Clermont-Ferrand]
31 CIC Brest
32 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
33 ANRS - MIE - ANRS - Maladies infectieuses émergentes
34 T-CRB Cancer Cochin - Tumorothèque - Centre de Ressources Biologiques Cancer Cochin [Hôpital Cochin AP-HP]
35 IMRB - Institut Mondor de Recherche Biomédicale
36 VRI - Vaccine Research Institute [Créteil, France]
37 HEGP - Hôpital Européen Georges Pompidou [APHP]
38 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire

Résumé

Abstract Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.

Dates et versions

hal-04741758 , version 1 (17-10-2024)

Identifiants

Citer

Christine Durier, Laetitia Ninove, Maeva Lefebvre, Anne Radenne, Corinne Desaint, et al.. Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years. Scientific Reports, 2022, 12 (1), pp.20373. ⟨10.1038/s41598-022-24409-w⟩. ⟨hal-04741758⟩
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