Communication Dans Un Congrès Année : 2009

Synthesis of cyclope-tides : constraints analogues of the peptide neurotoxin omega-agatoxin IVB

Résumé

For several years, our laboratory has been engaged in the enantioselective or diastereoselective synthesis of new compounds, primarily of nonprotein amino acids, in order to obtain pharmacological tools necessary to the study of the central nervous system and more precisely of the glutamate receptors which are essential in cerebral activities (memory, learning...) and which can be involved in certain pathologies (ischemia, epilepsy, disease of Huntington and Alzheimer ...). Specific anchoring of peptide neurotoxins on certain neurotransmitters receptors or membrane ionic channels, allow better understanding of neuronal transmission process in the CNS and thus the design of new drugs and therapeutic or preventive treatments.

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hal-04736180 , version 1 (14-10-2024)

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Valérie Rolland, Emilie Pringos, Jean Martinez. Synthesis of cyclope-tides : constraints analogues of the peptide neurotoxin omega-agatoxin IVB. Colloque du groupe français des peptides, Apr 2009, Aussois, France. ⟨hal-04736180⟩
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