Cycles of susceptibility: Immunity debt explains altered infectious disease dynamics post-pandemic - Archive ouverte HAL
Article Dans Une Revue Clinical Infectious Diseases Année : 2024

Cycles of susceptibility: Immunity debt explains altered infectious disease dynamics post-pandemic

Résumé

Non-pharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic suppressed not only transmission of SARS-CoV-2, but also many other endemic pathogens worldwide. Many of these pathogens would typically follow a seasonal circulation pattern, with annual resurgent epidemic waves largely influenced by levels of population immunity. This immunity wanes over time due to factors such as diminishing levels of specific antibodies, the birth of immunologically naive infants, and genetic mutations in the pathogen which diminish the efficacy of existing immunity. This slow reduction in population immunity leads to periodic increases in disease incidence until enough immunity is reestablished to suppress further transmission.
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hal-04731541 , version 1 (10-10-2024)

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  • HAL Id : hal-04731541 , version 1

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Alasdair P S Munro, Thomas House. Cycles of susceptibility: Immunity debt explains altered infectious disease dynamics post-pandemic. Clinical Infectious Diseases, In press. ⟨hal-04731541⟩
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