Acinetobacter baumannii: Setup and characterization of pneumonia and septicemia preclinical models with longitudinal monitoring using bioluminescent strains
Résumé
Bacterial multidrug resistance (MDR) is responsible of up to 4.9 million deaths, with the MDR ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp) being the leading cause of nosocomial infections worldwide. Treating these MDR bacteria represents one of the greatest challenges in clinical practice. Among ESKAPE pathogens, the emergence of rapidly spreading carbapenem- resistant Acinetobacter baumannii, combined to the lack of available active antibiotics has led the WHO to raise the threat level to "Urgent" and classify it in the critical group of its Bacterial Priority Pathogens List (2024). These observations call for an urgent need for new anti-microbials. The goal of this study was to setup preclinical models mimicking the main clinical infections caused by A. baumannii (bacteraemia and pneumonia) using bioluminescent strains that allow to perform longitudinal monitoring of the bacterial dissemination and assess antibacterial candidate’s efficacy
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