From Fluorinated Emerging Groups to Isotopic Labeled Molecules: New Tools for Medicinal Chemistry
Résumé
In order to develop new drug candidates for emerging pathologies and with a higher selectivity, new tools are required to synthesize new molecules with dedicated properties. Furthermore, for a better understanding of the physiologic mechanisms of pathologies and to better determine the pharmacokinetic behavior of drugs, new tools for in vivo functional imaging are required. In these two objectives, we developed several methods not only to synthesize fluorinated molecules with specific properties but also to obtain isotopic labeled molecules which can be used in medical imaging. The present lecture will highlight the development of new reagents and methods to introduce emerging fluorinated groups in order to modulate physico-chemical properties of molecules. In particular, association of fluorinated moieties with heteroatoms will be discussed. We will also present some innovative methods to easily obtain isotopic labeled molecules, from deuterium to positron emetting isotopes (18F and 11C), which can find uses in pharmacology or in vivo imaging.