Subthalamic Nucleus Stimulation is Efficient over the Time in Parkinson's Disease: A Clinical Evaluation
Résumé
Context: The management of Parkinson’s disease poses a real problem for the clinician. Stimulation of the subthalamic nucleus is a certain therapeutic hope, even if it does not stop the evolutionary genius of the disease. Objective: To evaluate the evolution over time of the effect of stimulation of the subthalamic nucleus on clinical parameters of Parkinson’s disease. Patients and Method: The UPDRS scores of 51 patients followed in the context of a neurology consultation were evaluated in ON/OFF STIM conditions. Beyond the overall UPDRS score, sub-scores relating to akineto-rigid signs and axial signs were also evaluated in the context of an experimental study. The statistical analysis used a classical linear model. A threshold of statistical significance was retained for p < 0.05. Results: It appeared that, for the UPDRS global score, there is a significant and persistent ON vs OFF difference in the time interval studied. This difference ON vs OFF was also found significantly and persistently for the subscores relating to the axial signs and the akineto-rigid signs. Conclusion: Our results show that the effect of stimulation of the subthalamic nucleus on the global UPDRS score and the sub-scores relating to akineto-rigid and axial signs is real and persistent during the time interval studied.