This chapter introduces a conceptual framework to reflect on the links between social inequalities in daily mobility and social inequalities in health. It describes the mechanisms through which social inequalities in daily mobility can contribute to social inequalities in health. The chapter aims to apply the conceptual framework to a contemporary issue, the Covid-19 pandemic, in order to illustrate the way in which mobility and the activity locations of more or less marginalized groups could put them at risk of contracting the disease, or suffering from the pandemic's psychosocial and collateral impacts. Conceptual framework can help to identify different mechanisms through which social inequalities in daily mobility could lead to social inequalities in health. The chapter concludes with a brief discussion on some practical implications of the conceptual framework for creating healthy and equitable cities.