Mechanisms of endocrine disruption through nuclear receptors and related pathways - Archive ouverte HAL
Article Dans Une Revue Current Opinion in Endocrine and Metabolic Research Année : 2019

Mechanisms of endocrine disruption through nuclear receptors and related pathways

Résumé

Endocrine-disrupting chemicals (EDCs) are a broad class of molecules present in our environment that are suspected to cause adverse effects in the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous hormones. Humans are generally exposed to low doses of pollutants, and current researches aim at deciphering the mechanisms accounting for the health impact of EDCs at environmental concentrations. Here, we review different mechanisms through which EDCs might alter hormonal functions by interfering with the nuclear receptors and related pathways, including extranuclear signaling by membrane-bound receptors mediating rapid non-genomic responses, and the aryl hydrocarbon receptor.
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hal-04707423 , version 1 (25-09-2024)

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Patrick Balaguer, Vanessa Delfosse, William Bourguet. Mechanisms of endocrine disruption through nuclear receptors and related pathways. Current Opinion in Endocrine and Metabolic Research, 2019, 7, pp.1-8. ⟨10.1016/j.coemr.2019.04.008⟩. ⟨hal-04707423⟩
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