Since 1971, UNESCO's Man and the Biosphere (MAB) Programme has embraced a number of principles that link the political, scientific and academic spheres. Biosphere Reserves and Sustainable Development Goals 1 presents these areas as privileged spaces for experimenting with operating methods specific to cross-cutting objectives and issues. These areas encourage the development of interdisciplinary research, supported by a worldwide network to disseminate experience, approaches and know-how. The various global and local political scales are linked here, with different consequences for the reconfiguration of local political arenas, for specific modes of development linked to a renewed relationship with knowledge, powers and institutions, and for renewed relationships between the worlds of science, education and territorial governance.