Tunable approach for the stereoselective synthesis of 1- C -diethylphosphono(difluoromethyl) iminosugars as glycosyl phosphate mimics
Résumé
An efficient methodology for the stereoselective and tunable addition of LiCF$_2$P(O)(OEt)$_2$ and BrMgCF$_2$P(O)(OEt)$_2$ reagents to N-t-butanesulfinyl glycosylamines is described with details on the stereochemical effects at play in this process. It provides a practical route to various 1-C-diethylphosphono(difluoromethyl) iminosugars as glycosyl phosphate and sugar nucleotide mimics.
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