Marine organisms continually adapt their physiology and behaviour to temporal variations in their environment, resulting in diurnal rhythmic behaviour, particularly when foraging. In delphinids, these rhythms can be studied by recording echolocation clicks, which can provide indicators of foraging activity. The foraging rhythms of delphinids and their relationship to temporal parameters are poorly documented and most studies so far have used moored passive acoustic systems. The present study provides, for the first time, information on the activity rhythms of delphinids investigated in relation with temporal variables at a basin scale from a moving platform, in the western and central Mediterranean Sea. We used passive acoustic recordings collected by hydrophones towed along transect lines during the ACCOBAMS Survey Initiative in the summer 2018. We extracted variables that may influence daily and monthly rhythms, including time of day, lunar cycle, lunar illumination and sea state and fitted generalised additive models. The nycthemeral and lunar cycles were the two main factors influencing dolphin activity rhythms. Echolocation activity was predominant at night, with a maximum of 0.026 acoustic events per minute at 21:00/22:00 compared to as few as 0.0007 events per minute at 11:00. These events were also more frequent during the third quarter of the moon; 0.033 acoustic events on day 22 of the lunar cycle as opposed to 0.0008 on day 8 of the lunar cycle, corresponding to the first quarter of the moon. Variations in the echolocation activity of delphinids in the Mediterranean Sea could reflect variation in their foraging effort and be related to prey density, composition, accessibility and catchability within dolphin foraging depth range. These results should also improve interpretation of passive acoustic monitoring data.