Additive‐Free Pd/In2O3‐Catalyzed N‐methylation of Primary Amides by Using Formic Acid
Résumé
Here we report on the use of formic acid as a green and safe reagent for the N‐methylation of primary amides in the presence of a Pd/In 2 O 3 solid catalyst. No additive is needed and primary amides are selectively N‐methylated in good to excellent yields. The reaction operates through a formylation/reduction pathway, leaving the amide carbonyl untouched.
| Origine | Fichiers produits par l'(les) auteur(s) |
|---|