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Article Dans Une Revue Chromosoma Année : 2023

Casting histone variants during mammalian reproduction

Germaine Karam
  • Fonction : Auteur
Antoine Molaro

Résumé

Abstract During mammalian reproduction, germ cell chromatin packaging is key to prepare parental genomes for fertilization and to initiate embryonic development. While chromatin modifications such as DNA methylation and histone post-translational modifications are well known to carry regulatory information, histone variants have received less attention in this context. Histone variants alter the stability, structure and function of nucleosomes and, as such, contribute to chromatin organization in germ cells. Here, we review histone variants expression dynamics during the production of male and female germ cells, and what is currently known about their parent-of-origin effects during reproduction. Finally, we discuss the apparent conundrum behind these important functions and their recent evolutionary diversification.

Domaines

Gamétogenèse

Dates et versions

hal-04686842 , version 1 (04-09-2024)

Identifiants

Citer

Germaine Karam, Antoine Molaro. Casting histone variants during mammalian reproduction. Chromosoma, 2023, 132 (3), pp.153-165. ⟨10.1007/s00412-023-00803-9⟩. ⟨hal-04686842⟩
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