Psychopharmacology in children and adolescents : unmet needs and opportunities
Samuele Cortese
(1, 2, 3, 4)
,
Diane Purper-Ouakil
(5, 6)
,
Alan Apter
(7, 8)
,
Celso Arango
(9, 10, 11, 12, 13)
,
Inmaculada Baeza
(14, 15, 11, 16)
,
Tobias Banaschewski
(17)
,
Jan Buitelaar
(18, 19)
,
Josefina Castro-Fornieles
(14, 15, 11, 16)
,
David Coghill
(20, 21)
,
David Cohen
(22, 23, 24)
,
Christoph U. Correll
(25, 26, 27)
,
Edna Grünblatt
(28, 29, 30)
,
Pieter J. Hoekstra
(31, 32)
,
Anthony James
(33, 34)
,
Pia Jeppesen
(35)
,
Péter Nagy
(36)
,
Anne Katrine Pagsberg
(35, 37)
,
Mara Parellada
(9, 10, 12, 11, 13)
,
Antonio M. Persico
(38)
,
Veit Roessner
(39)
,
Paramala Santosh
(40)
,
Emily Simonoff
(40, 41)
,
Dejan Stevanovic
(42, 43)
,
Argyris Stringaris
(44, 45)
,
Benedetto Vitiello
(46)
,
Susanne Walitza
(28, 29)
,
Abraham Weizman
(47, 7)
,
Ian C.K. Wong
(44, 48, 49)
,
Gil Zalsman
(47, 50, 7)
,
Alessandro Zuddas
(51)
,
Sara Carucci
(51)
,
Florence Butlen-Ducuing
(52)
,
Maria Tome
(52)
,
Myriam Bea
,
Christine Getin
,
Nina Hovén
,
Asa Konradsson-Geuken
(53)
,
Daphne Lamirell
,
Nigel Olisa
,
Begonya Nafria Escalera
(54)
,
Carmen Moreno
(9, 10, 11, 13, 12)
1
University of Southampton
2 NYU - New York University [New York]
3 UON - University of Nottingham, UK
4 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 CHU Montpellier = Montpellier University Hospital
7 Schneider Children’s Medical Center of Israel [Petah Tikva]
8 RUNI - Reichman University [Herzliya]
9 Hospital General Universitario "Gregorio Marañón" [Madrid]
10 IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón / Institute of Health Research Gregorio Marañón [Madrid, Spain]
11 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
12 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
13 ISCIII - Instituto de Salud Carlos III [Madrid]
14 UB - Universitat de Barcelona
15 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
16 CNM - Centro Nacional de Microbiología [ISCIII, Madrid, Spain]
17 University of Heidelberg, Medical Faculty
18 Radboud University Medical Center [Nijmegen]
19 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
20 University of Melbourne
21 MCRI - Murdoch Children's Research Institute
22 CHU Pitié-Salpêtrière [AP-HP]
23 SU - Sorbonne Université
24 ISIR - Institut des Systèmes Intelligents et de Robotique
25 Charité - UniversitätsMedizin = Berlin University Medicine
26 The Feinstein Institute for Medical Research
27 Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
28 University hospital of Zurich [Zurich]
29 UZH - Universität Zürich [Zürich] = University of Zurich
30 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
31 University of Groningen [Groningen]
32 UMCG - University Medical Center Groningen [Groningen]
33 University of Oxford
34 Oxford Health NHS Foundation Trust
35 UCPH - University of Copenhagen = Københavns Universitet
36 Pál Heim Children's Hospital = Heim Pál Gyermekkórház [Budapest]
37 Copenhagen University Hospital
38 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
39 TU Dresden - Technische Universität Dresden = Dresden University of Technology
40 King‘s College London
41 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
42 Institute of Neuroscience and Physiology [Göteborg]
43 GU - Göteborgs Universitet = University of Gothenburg
44 UCL - University College of London [London]
45 NKUA - National and Kapodistrian University of Athens
46 UNITO - Università degli studi di Torino = University of Turin
47 TAU - Tel Aviv University
48 HKU - The University of Hong Kong
49 Aston University [Birmingham]
50 Columbia University [New York]
51 University of Cagliari
52 EMA - European Medicines Agency = Agence européenne des médicaments [Amsterdam]
53 Uppsala University
54 Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain]
2 NYU - New York University [New York]
3 UON - University of Nottingham, UK
4 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 CHU Montpellier = Montpellier University Hospital
7 Schneider Children’s Medical Center of Israel [Petah Tikva]
8 RUNI - Reichman University [Herzliya]
9 Hospital General Universitario "Gregorio Marañón" [Madrid]
10 IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón / Institute of Health Research Gregorio Marañón [Madrid, Spain]
11 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
12 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
13 ISCIII - Instituto de Salud Carlos III [Madrid]
14 UB - Universitat de Barcelona
15 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
16 CNM - Centro Nacional de Microbiología [ISCIII, Madrid, Spain]
17 University of Heidelberg, Medical Faculty
18 Radboud University Medical Center [Nijmegen]
19 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
20 University of Melbourne
21 MCRI - Murdoch Children's Research Institute
22 CHU Pitié-Salpêtrière [AP-HP]
23 SU - Sorbonne Université
24 ISIR - Institut des Systèmes Intelligents et de Robotique
25 Charité - UniversitätsMedizin = Berlin University Medicine
26 The Feinstein Institute for Medical Research
27 Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
28 University hospital of Zurich [Zurich]
29 UZH - Universität Zürich [Zürich] = University of Zurich
30 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
31 University of Groningen [Groningen]
32 UMCG - University Medical Center Groningen [Groningen]
33 University of Oxford
34 Oxford Health NHS Foundation Trust
35 UCPH - University of Copenhagen = Københavns Universitet
36 Pál Heim Children's Hospital = Heim Pál Gyermekkórház [Budapest]
37 Copenhagen University Hospital
38 UNIMORE - Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia
39 TU Dresden - Technische Universität Dresden = Dresden University of Technology
40 King‘s College London
41 SLAM - South London and Maudsley NHS Mental Health Foundation Trust
42 Institute of Neuroscience and Physiology [Göteborg]
43 GU - Göteborgs Universitet = University of Gothenburg
44 UCL - University College of London [London]
45 NKUA - National and Kapodistrian University of Athens
46 UNITO - Università degli studi di Torino = University of Turin
47 TAU - Tel Aviv University
48 HKU - The University of Hong Kong
49 Aston University [Birmingham]
50 Columbia University [New York]
51 University of Cagliari
52 EMA - European Medicines Agency = Agence européenne des médicaments [Amsterdam]
53 Uppsala University
54 Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain]
Celso Arango
- Fonction : Auteur
Mara Parellada
- Fonction : Auteur
Myriam Bea
- Fonction : Auteur
Christine Getin
- Fonction : Auteur
Nina Hovén
- Fonction : Auteur
Daphne Lamirell
- Fonction : Auteur
Nigel Olisa
- Fonction : Auteur
Carmen Moreno
- Fonction : Auteur
Résumé
Psychopharmacological treatment is an important component of the multimodal intervention approach to treating mental health conditions in children and adolescents. Currently, there are many unmet needs but also opportunities, alongside possible risks to consider, regarding the pharmacological treatment of mental health conditions in children and adolescents. In this Position Paper, we highlight and address these unmet needs and opportunities, including the perspectives of clinicians and researchers from the European College of Neuropsychopharmacologyu2013Child and Adolescent Network, alongside those of experts by lived experience from national and international associations, via a survey involving 644 participants from 13 countries, and of regulators, through representation from the European Medicines Agency. We present and discuss the evidence base for medications currently used for mental disorders in children and adolescents, medications in the pipeline, opportunities in the development of novel medications, crucial priorities for the conduct of future clinical studies, challenges and opportunities in terms of the regulatory and legislative framework, and innovations in the way research is conducted, reported, and promoted.