Atroposelective Construction of Axially Chiral 2-Aryl-Pyrroloquinolones
Résumé
A two-step protocol including an enantioselective organocatalyzed synthesis of pyrroloquinolines followed by an oxidation reaction allowed the formation of axially chiral 2-aryl-pyrroloquinolones. Thorough optimization of the experimental conditions for the second step allowed the oxygenation reaction to take place and ensured, in most cases, a central-to-axial chirality conversion with complete retention of the enantiomeric excess
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