Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2024

Photocatalytic α‐Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers

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Abstract We present a metal‐free photocatalytic approach for the synthesis of difluoroalkoxylatedketones. This strategy involves the generation of alkoxyl radicals from pyridinium salts upon the activity of a catalytic electron‐donor‐acceptor (EDA) complex. This mild process tolerates several functional groups and can be scaled up to gram scale. Diverse products manipulations accounts for the versatility of the obtained fluorinated products, highlighting the synthetic usefulness of this method.

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hal-04680319 , version 1 (22-05-2025)

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Julien Paut, Simone Baldon, Elsa Anselmi, Luca Dell'Amico, Guillaume Dagousset, et al.. Photocatalytic α‐Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers. Advanced Synthesis and Catalysis, 2024, ⟨10.1002/adsc.202400510⟩. ⟨hal-04680319⟩
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