Chemoenzymatic Synthesis of Enantiomerically Pure (2S,3R,4S)‐4‐Hydroxyisoleucine, an Insulinotropic Amino Acid Isolated from Fenugreek Seeds
Résumé
A short six‐step synthesis of (2S,3R,4S)‐4‐hydroxyisoleucine (1a) with total control of stereochemistry is reported, the last step being the enzymatic resolution by hydrolysis of a N ‐phenylacetyl lactone derivative using the commercially available penicillin acylase G immobilized on Eupergit C (E‐PAC).
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