This paper presents Adaptive Meta-Domain Transfer Learning (AMDTL), a novel methodology that combines principles of meta-learning with domain-specific adaptations to enhance the transferability of artificial intelligence models across diverse and unknown domains. AMDTL aims to address the main challenges of transfer learning, such as domain misalignment, negative transfer, and catastrophic forgetting, through a hybrid framework that emphasizes both generalization and contextual specialization. The framework integrates a meta-learner trained on a diverse distribution of tasks, adversarial training techniques for aligning domain feature distributions, and dynamic feature regulation mechanisms based on contextual domain embeddings. Experimental results on benchmark datasets demonstrate that AMDTL outperforms existing transfer learning methodologies in terms of accuracy, adaptation efficiency, and robustness. This research provides a solid theoretical and practical foundation for the application of AMDTL in various fields, opening new perspectives for the development of more adaptable and inclusive AI systems.