Unraveling the intricacies of host-pathogen interaction through single-cell genomics - Archive ouverte HAL
Article Dans Une Revue Microbes and Infection Année : 2024

Unraveling the intricacies of host-pathogen interaction through single-cell genomics

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Single-cell genomics provide researchers with tools to assess host-pathogen interactions at a resolution previously inaccessible. Transcriptome analysis, epigenome analysis, and immune profiling techniques allow for a better comprehension of the heterogeneity underlying both the host response and infectious agents. Here, we highlight technological advancements and data analysis workflows that increase our understanding of host-pathogen interactions at the single-cell level. We review various studies that have used these tools to better understand host-pathogen dynamics in a variety of infectious disease contexts, including viral, bacterial, and parasitic diseases. We conclude by discussing how single-cell genomics can advance our understanding of host-pathogen interactions.
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hal-04671689 , version 1 (16-08-2024)

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Emanuele Gioacchino, Koen Vandelannoote, Anthony A Ruberto, Jean Popovici, Tineke Cantaert. Unraveling the intricacies of host-pathogen interaction through single-cell genomics. Microbes and Infection, In press, pp.105313. ⟨10.1016/j.micinf.2024.105313⟩. ⟨hal-04671689⟩
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