High-resolution brain tractography from X-ray phase-contrast images - Archive ouverte HAL
Article Dans Une Revue The European Physical Journal Plus Année : 2024

High-resolution brain tractography from X-ray phase-contrast images

Résumé

X-ray phase contrast tomography (XPCT) can produce high contrast isotropic images of biological samples in only a few minutes thanks to the unique properties of the synchrotron X-ray beam. XPCT of brain tissue provides an exquisite contrast of white matter, which could be exploited for 3D directional analysis. In this article, we present the first XPCT-based pipeline to perform white matter tractography on rodent brains. We observed the disorganization of white matter in the vicinity of focal demyelinating lesions in the corpus callosum. The ability to obtain an isotropic, high-resolution tractogram is an important landmark which could drive further interest of the neuroscience community toward XPCT.
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Dates et versions

hal-04667082 , version 1 (02-08-2024)

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Joshua Gobé, Hugo Rositi, Antoine Vacavant, Margaux Rivière, Chrystelle Po, et al.. High-resolution brain tractography from X-ray phase-contrast images. The European Physical Journal Plus, 2024, Focus Point on Recent Advances in X-ray and Neutron Imaging for Cultural Heritage and Biomedicine, 139 (7), pp.571. ⟨10.1140/epjp/s13360-024-05357-y⟩. ⟨hal-04667082⟩
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