In vitro physiological effects and phytochemical exploration of four Sideritis L. species from Türkiye. - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2024

In vitro physiological effects and phytochemical exploration of four Sideritis L. species from Türkiye.

Résumé

Sideritis L. is a member of the Lamiaceae family. There are approximately 218 taxa in the world and 60 taxa in Türkiye belonging to the Sideritis genus. Among these 60 taxa, 40 are endemic to Türkiye (Duman, 2012; WFO, 2024). According to ethnobotanical studies, Sideritis species have been used in the treatment of skin disease, cold, cough, wound, diarrhoea (Tuzlacı, 2016). The Sideritis genus has a wide range of chemical components, including lignans, sterols, iridoids, terpenoids and flavonoids (González-Burgos, 2011). Four different Sideritis taxa were collected for this study from different localities and after identification stored at Herbarium of Altınbaş University, Faculty of Pharmacy (HERA). The ethanolic extracts of these four species were tested for their cytotoxicity on L929 fibroblast cells and their metabolic activities on keratinocyte cells (HaCat) and endothelial cells (HuVeC) in order to better understand their uses. Sideritis congesta P.H.Davis & Hub.-Mor. and Sideritis montana L. have proven ineffective on keratinocytes but demonstrated activation of dermal cells. Intriguingly, Sideritis trojana Bornm. selectively promote the division of HuVeC cells, while Sideritis germanicopolitana subsp. germanicopolitana Bornm. stimulate a more significant proliferation of fibroblast cells compared to the negative control group. Extracts have been analysed by UHPLC-DAD-ELSD and are mainly composed by flavonoids and terpenoids. Analysis have shown a large difference in terpenoids composition. UHPLC-HRMS/MS analysis are in progress to refine the compound identification and better understand the differences of physiological effects of these extracts.
Fichier non déposé

Dates et versions

hal-04654086 , version 1 (19-07-2024)

Identifiants

  • HAL Id : hal-04654086 , version 1

Citer

Ebru Özdemir Nath, Pierre-Eric Campos, Gül İpek Gündoğan. In vitro physiological effects and phytochemical exploration of four Sideritis L. species from Türkiye.. International Congress on Natural Products Research, Jul 2024, Krakow, Poland. ⟨hal-04654086⟩
0 Consultations
0 Téléchargements

Partager

Gmail Mastodon Facebook X LinkedIn More