Electropolymerization of pyrrole-based metal N-Heterocyclic carbenes for antibacterial applications - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2024

Electropolymerization of pyrrole-based metal N-Heterocyclic carbenes for antibacterial applications

Résumé

N-heterocyclic carbenes (NHCs) are strong σ-donor ligands capable of coordinating a large proportion of transition metals. Metal-NHC complexes have been firstly used for catalytic applications and are now seen as good and flexible moieties for the development of biologically active molecules [1]. Researchers have synthesized metal-NHC derivatives for antimicrobial and anticancer applications that have shown encouraging results, both in vitro and in vivo [2]. However, only simple complexes were tested and the possibility to use polymeric metal-NHC as bioactive materials is yet to be investigated. In this work, a new strategy has been explored to develop antibacterial surfaces from electroactive metal-NHC monomers. To achieve this purpose, a series of pyrrole-functionalized NHC complexes containing various transition metals (Cu, Ru, Rh, Ag, Au) were synthesized using mechanochemistry or classical solvent synthesis. The electropolymerization was carried out on gold surfaces using cyclic voltammetry to produce polypyrrole films. The obtained polymeric materials were fully characterized by Fourier Transform InfraRed spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), profilometry and water contact angle (WCA) analyses. The antibacterial activity of these novel materials has been measured against four different bacterial strains by the halo inhibition method. The metal-containing polypyrrole surfaces have shown good antibacterial activity that depends on the nature of the metal and the bacterial strain.

Domaines

Chimie
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Dates et versions

hal-04651155 , version 1 (17-07-2024)

Identifiants

  • HAL Id : hal-04651155 , version 1

Citer

Q. Gaudillat, H. Ben Halima, V. Humblot, A. Figarol, J. Bausells, et al.. Electropolymerization of pyrrole-based metal N-Heterocyclic carbenes for antibacterial applications. 7èmes journées plénières du GdR B2i (Bio-ingénierie des interfaces), Jul 2024, Mulhouse, France. . ⟨hal-04651155⟩
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