Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps - Archive ouverte HAL
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 1994

Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps

Résumé

Various chimeric oligonucleotides consisting of α- and β-anomeric deoxynucleotide units have been synthesized and their hybridizing abilities to complementary DNA or RNA single strands, and their stability in cell culture medium or cell extracts, were studied. The results provide guide lines for optimization of antisense chimeric oligodeoxynucleotides. Various chimeric oligonucleotides consisting of α- and β-anomeric deoxynucleotide units have been synthesized and their hybridizing abilities to complementary DNA or RNA single strands, and their stability in cell culture medium or cell extracts, were studied. The results provide guide lines for optimization of antisense chimeric oligodeoxynucleotides.

Domaines

Chimie

Dates et versions

hal-04651101 , version 1 (17-07-2024)

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Citer

Francoise Debart, Guilhem Tosquellas, Bernard Rayner, Jean-Louis Imbach. Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps. Bioorganic and Medicinal Chemistry Letters, 1994, 4 (8), pp.1041-1046. ⟨10.1016/S0960-894X(01)80678-8⟩. ⟨hal-04651101⟩
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