Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription - Archive ouverte HAL
Article Dans Une Revue FEBS Letters Année : 1995

Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription

Résumé

Alpha‐beta chimeric 17‐mer oligodeoxyribonucleotides containing either 5, 10 or 15 beta nucleotides were synthesized. The stability of the RNA/chimera hybrids was only slightly affected by the alpha stretch and by the alpha‐beta link, as was the affinity of the Moloney Murine Leukemia Virus reverse transcriptase for the duplexes. All chimeras inhibited in vitro cDNA synthesis in a cell‐free system to various extent, via the degradation of the RNA target by RNase H.

Domaines

Chimie

Dates et versions

hal-04650399 , version 1 (16-07-2024)

Identifiants

Citer

Claudine Boiziau, Françoise Debart, Bernard Rayner, Jean-Louis Imbach, Jean-Jacques Toulme. Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription. FEBS Letters, 1995, 361 (1), pp.41-45. ⟨10.1016/0014-5793(95)00138-y⟩. ⟨hal-04650399⟩
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