A bilingual (English and Portuguese) innovative teaching method, Stereochemistry Game, is presented in the form of a board/card game to help students in their studies of stereochemistry. Four decks of cards (280 cards in total) and one board have been developed for second-year organic chemistry students in an effort to have them work together to solve stereochemistry problems in the context of a fun board game and to provide an efficient alternative to traditional methods of learning. This game encourages interaction and communication among students, develops strategic thinking, and requires minimal preparation and supervision from the professor. Based on the feedback of students and the assessment of learning, the game can be used as a complementary didactic tool by students for aiding them to review and to learn topics related to stereochemistry in a fun way.