Mortality and Major Cardiovascular Events among Patients with Multiple Myeloma: Analysis from a Nationwide French Medical Information Database
Yves Cottin
(1, 2, 3, 4, 5, 6)
,
Mathieu Boulin
(1, 2, 3, 4, 5, 6, 7)
,
Clara Doisy
(1, 2, 3, 4, 5, 6)
,
Morgane Mounier
(3, 8, 9, 10)
,
Denis Caillot
(11)
,
Marie Lorraine Chretien
(1, 2, 3, 4, 5, 6)
,
Alexandre Bodin
(12, 13)
,
Julien Herbert
(12, 13)
,
Bernard Bonnotte
(1, 2, 3, 4, 5, 6, 13)
,
Marianne Zeller
(1, 2, 3, 4, 5, 6)
,
Marc Maynadié
(1, 2, 3, 4, 5, 6, 13)
,
Laurent Fauchier
(13, 12)
1
Service de Cardiologie [CHU de Dijon]
2 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
3 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
4 UFC UFR Santé - Université de Franche-Comté - UFR des Sciences de la santé
5 Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon]
6 Service d'hématologie biologique [CHU de Dijon]
7 Equipe EPICAD (LNC - U1231)
8 LabEx LipSTIC - Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer
9 Registre des hémopathies malignes de Côte d'Or
10 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
11 Hôpital du Bocage
12 CHU Trousseau [Tours]
13 EES - Éducation Éthique Santé EA 7505
2 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
3 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
4 UFC UFR Santé - Université de Franche-Comté - UFR des Sciences de la santé
5 Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon]
6 Service d'hématologie biologique [CHU de Dijon]
7 Equipe EPICAD (LNC - U1231)
8 LabEx LipSTIC - Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer
9 Registre des hémopathies malignes de Côte d'Or
10 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
11 Hôpital du Bocage
12 CHU Trousseau [Tours]
13 EES - Éducation Éthique Santé EA 7505
Yves Cottin
- Fonction : Auteur
- PersonId : 941967
Mathieu Boulin
- Fonction : Auteur
- PersonId : 1028678
- ORCID : 0000-0002-3504-7250
Clara Doisy
- Fonction : Auteur
- PersonId : 1397897
Morgane Mounier
- Fonction : Auteur
Marie Lorraine Chretien
- Fonction : Auteur
- PersonId : 1397898
Alexandre Bodin
- Fonction : Auteur
- PersonId : 1397899
Bernard Bonnotte
- Fonction : Auteur
- PersonId : 924453
Marianne Zeller
- Fonction : Auteur
- PersonId : 941968
Marc Maynadié
- Fonction : Auteur
- PersonId : 992990
Laurent Fauchier
- Fonction : Auteur
- PersonId : 1091686
- ORCID : 0000-0002-9267-1658
- IdRef : 05973843X
Résumé
Background: No robust data assesses the risk of all-cause death and cardiovascular (CV) events in multiple myeloma (MM) patients.
Patients and Methods: From 1 January to 31 December 2013, 3,381,472 adults were hospitalised (for any reason) in French hospitals. We identified 15,774 patients diagnosed with known MM at baseline. The outcome analysis (all-cause death, CV death, myocardial infarction (MI), ischaemic stroke, or hospitalization for bleedings) was performed with follow-ups starting at the time of the last event. For each MM patient, a propensity score-matched patient without MM was selected.
Results: The mean follow-up in the propensity-score-matched population was 3.7 ± 2.3 years. Matched patients with MM had a higher risk of all-death (yearly rate 20.02 vs. 11.39%) than patients without MM. No difference was observed between the MM group and no-MM group for CV death (yearly rate 2.00 vs. 2.02%). The incidence rate of MI and stroke was lower in the MM group: 0.86 vs. 0.97%/y and 0.85 vs. 1.10%/y, respectively. In contrast, MM patients had a higher incidence rate of rehospitalization for major bleeding (3.61 vs. 2.24%/y) and intracranial bleeding (1.03 vs. 0.84%/y).
Conclusions: From a large nationwide database, we demonstrated that MM patients do not have a higher risk of CV death or even a lower risk of both MI and ischaemic stroke. Conversely, MM patients had a higher risk of both major and intracranial bleedings, highlighting the key issue of thromboprophylaxis in these patients
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Background: No robust data assesses the risk of all-cause death and cardiovascular (CV) events in multiple myeloma (MM) patients.
Patients and Methods: From 1 January to 31 December 2013, 3,381,472 adults were hospitalised (for any reason) in French hospitals. We identified 15,774 patients diagnosed with known MM at baseline. The outcome analysis (all-cause death, CV death, myocardial infarction (MI), ischaemic stroke, or hospitalization for bleedings) was performed with follow-ups starting at the time of the last event. For each MM patient, a propensity score-matched patient without MM was selected.
Results: The mean follow-up in the propensity-score-matched population was 3.7 ± 2.3 years. Matched patients with MM had a higher risk of all-death (yearly rate 20.02 vs. 11.39%) than patients without MM. No difference was observed between the MM group and no-MM group for CV death (yearly rate 2.00 vs. 2.02%). The incidence rate of MI and stroke was lower in the MM group: 0.86 vs. 0.97%/y and 0.85 vs. 1.10%/y, respectively. In contrast, MM patients had a higher incidence rate of rehospitalization for major bleeding (3.61 vs. 2.24%/y) and intracranial bleeding (1.03 vs. 0.84%/y).
Conclusions: From a large nationwide database, we demonstrated that MM patients do not have a higher risk of CV death or even a lower risk of both MI and ischaemic stroke. Conversely, MM patients had a higher risk of both major and intracranial bleedings, highlighting the key issue of thromboprophylaxis in these patients
|
Titre |
en
Mortality and Major Cardiovascular Events among Patients with Multiple Myeloma: Analysis from a Nationwide French Medical Information Database
|
Auteur(s) |
Yves Cottin
1, 2, 3, 4, 5, 6
, Mathieu Boulin
1, 2, 3, 4, 5, 6, 7
, Clara Doisy
1, 2, 3, 4, 5, 6
, Morgane Mounier
3, 8, 9, 10
, Denis Caillot
11
, Marie Lorraine Chretien
1, 2, 3, 4, 5, 6
, Alexandre Bodin
12, 13
, Julien Herbert
12, 13
, Bernard Bonnotte
1, 2, 3, 4, 5, 6, 13
, Marianne Zeller
1, 2, 3, 4, 5, 6
, Marc Maynadié
1, 2, 3, 4, 5, 6, 13
, Laurent Fauchier
13, 12
1
Service de Cardiologie [CHU de Dijon]
( 198713 )
- CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon
- France
2
PEC2 -
Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
( 477904 )
- Université de Bourgogne - 21000 Dijon
- France
3
CHU Dijon -
Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
( 300924 )
- CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon
- France
4
UFC UFR Santé -
Université de Franche-Comté - UFR des Sciences de la santé
( 1095272 )
- 19 rue Ambroise Paré - CS 71806 - 25030 Besançon cedex
- France
5
Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon]
( 476496 )
- CHU de Dijon - 14 Rue Paul Gaffarel, 21000 Dijon
- France
6
Service d'hématologie biologique [CHU de Dijon]
( 209248 )
- CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon
- France
7
Equipe EPICAD (LNC - U1231)
( 1096462 )
- Université de Bourgogne - Faculté de médecine - 7, Bld Jeanne d'Arc - BP 87900 - 21079 DIJON CEDEX
- France
8
LabEx LipSTIC -
Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer
( 1002423 )
- Faculté de Médecine - 7 boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex
- France
9
Registre des hémopathies malignes de Côte d'Or
( 321039 )
- Faculté de médecine
7, bd Jeanne d'Arc
- France
10
LNC -
Lipides - Nutrition - Cancer [Dijon - U1231]
( 489317 )
- Université de Bourgogne - Faculte de medecine - 7, boulevard Jeanne d'Arc - BP 87900 - 21079 Dijon Cedex
- France
11
Hôpital du Bocage
( 74037 )
- 2, boulevard Maréchal-de-Lattre-de-Tassigny, 21000 Dijon
- France
12
CHU Trousseau [Tours]
( 12089 )
- CHU Trousseau, Unité de Médecine et Physiologie Spatiale, F-37044 Tours
- France
13
EES -
Éducation Éthique Santé EA 7505
( 551581 )
- Université François-Rabelais Tours
Faculté de Médecine
Département de Médecine Générale - Secrétariat
10 Boulevard Tonnellé
BP 3223
37032 TOURS Cédex 1
- France
|
Date de publication électronique |
2022-06-21
|
Date de publication |
2022
|
Numéro |
13
|
Page/Identifiant |
3049
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Langue du document |
Anglais
|
Nom de la revue |
|
Volume |
14
|
Domaine(s) |
|
Mots-clés |
en
multiple myeloma, myocardial infarction, ischaemic stroke, bleeding, mortality
|
DOI | 10.3390/cancers14133049 |
Origine :
Fichiers éditeurs autorisés sur une archive ouverte
Loading...