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Article Dans Une Revue Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism Année : 2024

Polyamine metabolism in macrophage–adipose tissue function and homeostasis

Résumé

Intracellular metabolism is a crucial regulator of macrophage function. Recent evidence revealed that the polyamine pathway and subsequent hypusination of eukaryotic initiation factor 5A (eIF5A) are master regulators of immune cell functions. In brown adipose tissue (BAT), macrophages show an impressive degree of heterogenicity, with specific subsets supporting adaptive thermogenesis during cold exposure. In this review, we discuss the impact of polyamine metabolism on macrophage diversity and function, with a particular focus on their role in adipose tissue homeostasis. Thus, we highlight the exploration of how polyamine metabolism in macrophages contributes to BAT homeostasis as an attractive and exciting new field of research
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Dates et versions

hal-04633458 , version 1 (03-07-2024)

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Didier F Pisani, Daniele Lettieri-Barbato, Stoyan Ivanov. Polyamine metabolism in macrophage–adipose tissue function and homeostasis. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , In press, ⟨10.1016/j.tem.2024.05.008⟩. ⟨hal-04633458⟩
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