Towards elimination of chronic viral hepatitis in French Polynesia: results from a national population-based survey - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue The Lancet Regional Health - Western Pacific Année : 2024

Towards elimination of chronic viral hepatitis in French Polynesia: results from a national population-based survey

Iotefa Teiti

Résumé

Background: In French Polynesia, hepatitis B virus (HBV) infection appears as a major risk factor for hepatocellular carcinoma (HCC), which detection rate in the Austral archipelago is among the highest in the world. Through a nationally representative cross-sectional survey of the adult population, this study aimed at assessing the prevalence of HBV, but also hepatitis C virus (HCV), and hepatitis delta virus (HDV).Methods: A total of 1942 blood samples from participants aged 18-69 years were tested for anti-HBc, anti-HBs, HBsAg, anti-HCV IgG, and HDV RNA. Complete genome sequencing of detected HBV strains was performed.Findings: Among participants, 315/1834, 582/1834, 33/1834, 0/1857, and 0/33 tested positive for anti-HBc, anti-HBs, HBsAg, anti-HCV IgG, and HDV RNA, respectively. The population prevalence of HBsAg was estimated at 1.0% (95% CI: 0.6-1.7). All HBsAg carriers were born in French Polynesia before vaccination at birth became mandatory. In multivariate analyses, identified factors associated with HBsAg carriage included: the archipelago of residence (p < 0.0001), age (p < 0.0001), and education level (p = 0.0077). HBV genotypes B, C, and F were detected.Interpretation: French Polynesia has a low endemicity level of HBV and its population may be considered at low risk for HCV and HDV infection. However, prevalence of HBsAg was found concerning in Austral (3.8%; 95% CI: 1.9-7.5) and Marquesas (6.5%; 95% CI: 3.8-11) archipelagoes. In the Austral archipelago, the presence of genotype C may account for the elevated rate of HCC. Our findings warrant more efforts to improve access to detection, prevention and care to people born before the systematic vaccination policy application, and residing in higher-risk areas, to achieve HBV elimination in French Polynesia.
Fichier principal
Vignette du fichier
1-s2.0-S2666606524000294-main.pdf (1.35 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04633430 , version 1 (03-07-2024)

Licence

Identifiants

Citer

Iotefa Teiti, Maite Aubry, Philippe Glaziou, Vincent Mendiboure, Anita Teissier, et al.. Towards elimination of chronic viral hepatitis in French Polynesia: results from a national population-based survey. The Lancet Regional Health - Western Pacific, 2024, 45, pp.101035. ⟨10.1016/j.lanwpc.2024.101035⟩. ⟨hal-04633430⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More